Striker Hanson sustained a groin injury in last Saturday's home win over Wycombe, while midfielder Syers strained his hamstring .
Manager Peter Taylor is expected to recall Gareth Evans up front and on-loan Tom Adeyemi into midfield in place of Syers.
Taylor could also be tempted to start with either Steve Williams or Shane Duff alongside Luke Oliver in central defence in place of Lewis Hunt to combat the aerial threat of Vale strikers Tom Pope and Justin Richards.
Midfielders Tommy Doherty (ankle), Leon Osborne (hamstring) and Lee Bullock (hip) remain sidelined, but strikers Scott Dobie and Kevin Ellison are expected to keep their places in Taylor's starting line-up after both making their debuts for the Bantams last week.
Source: PA
Source: PA